Human Development Research Articles

Personalized lung care: Bronchopulmonary dysplasia risk prediction tool tailored for neonates born in resource-limited settings.

Predicting bronchopulmonary dysplasia (BPD) to assess the risk-benefit of therapy is necessary considering the side effects of medications. We developed and validated an instrument for predicting BPD and compared it with an instrument currently used for neonates born in a Brazilian hospital. This was a retrospective cohort study of patients born between 2016 and 2020 with a gestational age (GA) between 23 and 30 weeks. Predictive equations were elaborated using methods of component variable selection collected on the 14th day of life; 70% of the sample was randomly selected for the construction of risk prediction equations and the remaining 30% for their validation, application, and comparison with the National Institute of Child Health and Human Development (NICHD) instrument. The sensitivity, specificity, and predictive values of the equations were calculated. The equation that used variables with p < 5% in Fisher's exact test presented the best results: specificity of 98% and positive predictive value of 93% and could be used for BPD prediction of all small-for-gestational-age (SGA) infants. The NICHD calculator applied to our population had a specificity of 93% and a positive predictive value of 75% and could not be applied to extremely SGA infants. Our tool can predict the risk of BPD on the 14th day of life, has higher specificity and positive predictive value to our population than the NICHD instrument, and can be suitable for SGA infants. The results must be confirmed by applying it to other populations to validate our tool.

Can financial inclusion enhance human development? Evidence from low- and middle-income countries

The purpose of this study is to determine if financial inclusion in low-, lower-middle-, and upper-middle-income nations promotes human development. Our aim was accomplished by employing an empirical technique of using the System Generalized Method of Moments (SGMM) and dynamic threshold panel (DTP) data on a sample of 79 nations between 2000 and 2017. Three sub-samples representing low-, lower-, and upper-middle-income nations were created from the entire sample. In general, lower- and upper-middle-income nations’ human development is positively impacted by financial inclusion, according to SGMM empirical studies. Furthermore, the DTP method’s results show that there is a threshold impact for both human development and financial inclusion. The degree of human development in upper-middle-income and lower-middle-income countries is greatly raised by financial inclusion, whether the threshold is met or beyond.

The beginning of becoming a human.

According to birth certificates, the life of a child begins once their body comes out of the mother's womb. But when does their organismal life begin? Science holds a palette of answers-depending on how one defines a human life. In 1984, a commission on the regulatory framework for human embryo experimentation opted not to answer this question, instead setting a boundary, 14 days post-fertilization, beyond which any experiments were forbidden. Recently, as the reproductive technologies developed and the demand for experimentation grew stronger, this boundary may be set aside leaving the ultimate decision to local oversight committees. While science has not come closer to setting a zero point for human life, there has been significant progress in our understanding of early mammalian embryogenesis. It has become clear that the 14-day stage does in fact possess features, which make it a foundational time point for a developing human. Importantly, this stage defines the separation of soma from the germline and marks the boundary between rejuvenation and aging. We explore how different levels of life organization emerge during human development and suggest a new meaning for the 14-day stage in organismal life that is grounded in recent mechanistic advances and insights from aging studies.

Comparison of Weights in Weighted Least Square Method For Handling Heteroscedasticity on Multiple Regression Model

Regression analysis is the most popular and commonly used to determine causality between two or more variables. In regression analysis there are several assumptions that must be held, so that the property of the best linear unbiased estimator (BLUE) is still guaranteed. In fact, we often found violations of the assumptions.  One of them was violations of the homoscedasticity or occurs heteroscedasticity. The impact of heteroscedasticity in the regression model is that the ordinary least square (OLS) estimator no longer has a minimum variance although still linear and unbiased. To handle this, weighted least square (WLS) regression is used instead, which giving weights on the observations. But the problem often encountered is choosing which the best weight in WLS method. This paper aimed to compare and determine the best weight among 1/X, 1/ , 1/Y and 1/s in multiple regression model. Human development index factors data, which were obtained from the Indonesian Central Bureau of Statistics, were used. The results showed that the best weight on human development index data was 1/s.  The coefficient of determination was 98.7% indicating that the model was very good.

Agile Management Practices and Project Performance in Rwandan Schools: A Case of Rwanda Quality Basic Education for Human Capital Development Project

Agile Management Practices and Project Performance in Rwandan Schools: A Case of Rwanda Quality Basic Education for Human Capital Development Project

Literature Review: The Relationship Between Technology Development, the Digital Era, and HRD In Indonesia's Underdeveloped Regions

This study aimed to find the relationship between technology development and human resource development in underdeveloped areas, especially in Indonesia. The effect of technological development in the digital era is really good, but there are fewer facilities in underdeveloped areas. This was a literature review study. The sources for this literature review were indexed journals and proceedings on Google Scholars from 2019 onwards. There was only one journal before 2019, which was in 2017. With low human resources and minimal access to the internet, human resources in remote areas are threatened with being left behind in facing the changing times brought by the digital era. This research was limited to a general overview of remote areas and their impacts on existing conditions in the digital era. This research can contribute to policy building by the government by giving some views about the condition of the digital era and its impact on human resource development. This research also showed the importance of human resource development in underdeveloped areas. This research can also be a reference for future research on human resource development, the digital era, and the underdeveloped regions in Indonesia. Keywords: human resource development, digital era, change, underdeveloped area, facility

The Impact of Regional Expenditures on the Quality of Human Development in South Sumatra

The quality of human development depends on the level of fulfillment of their needs in the fields of health, education, and per capita spending. The government as a driver of development activities has a vital role in human development, especially after the pandemic era which previously had a negative impact on people’s quality of life. Through an effective regional budget allocation, the government can continue to improve the quality of human development toward the expected goals of prosperity. This study seeks to describe the effect of regional spending on the quality of human development in South Sumatra Province. The data used is time series data for 2006–2022. The analysis used is simple linear regression. The results obtained are that regional spending has a positive and significant effect on the Human Development Index (HDI). This means that the quality of human development in South Sumatra depends on regional expenditure activities in sectors that support the HDI component. Keywords: regional expenditures, HDI

Urbanization intensifies the imbalance between human development and biodiversity conservation: Insights from the coupling analysis of human activities and habitat quality

AbstractIntensified human activities have been seriously threatening the structure and ecological processes of ecosystems, resulting in habitat degradation. Therefore, coordinating the coupling between human activities and habitat quality (HQ) is crucial for high‐quality sustainable regional development and human well‐being. This study evaluated the human activities and HQ in the Pearl River Delta (PRD) urban agglomeration in China from 2000 to 2020 using the human footprint index (HFI) and the integrated valuation of ecosystem services and tradeoffs model. Then, we employed bivariate spatial autocorrelation and a coupling coordination degree (CCD) model to explore the synergistic relationship between human activities and HQ. The results show that spatial changes in HQ were predominantly driven by human activities. The gradual outward urban expansion resulted in significant HQ degradation. Slight HQ improvement by ecological restoration in urban outskirts cannot offset HQ losses caused by urbanization. During the study period, high‐HQ low‐HFI clusters decreased by 1.02%, while low‐HQ high‐HFI clusters increased by 4.67%, the two main clustering types in the PRD. Despite the CCD between HFI and HQ increased after 2010, the continuous changes of CCD characteristics from the HFI significantly lagged type to the HQ lagged. HFI showed an inverted U‐shaped relationship with CCD. The CCD peaks during 2000–2020 corresponded to HFI decreasing from 0.711 to 0.566. This indicates that the risk of decoupling between human activities and HQ gradually increased. Furthermore, CCD levels and characteristics in different bivariate clusters exhibited varying changes over time. These results reveal that the spatiotemporal dislocation between urbanization and ecological restoration induced the spatial nonstationarity of the coupling relationship between human activities and HQ. Urbanization exacerbates the imbalance between human development and biodiversity conservation. Therefore, we suggest reasonably delimiting urban boundaries, controlling the scale of urban sprawl, and strengthening biodiversity protection in areas undergoing rapid urbanization. In addition, we advocate for the division of ecological barrier zones, urban development buffer zones, and urban built‐up areas, each with tailored management and protection measures. Our findings can provide an important reference for the ecological restoration of urban agglomerations.

Asymmetric effects of long-term war on human resource development in Af…ghanistan: evidence from NARDL approach

AbstractThis study explores the effects of war on human resource development in Afghanistan using non-linear autoregressive distributed lags (NARDL) and asymmetric causality analysis. The results of the NARDL bound test support an asymmetric long-run relationship between predictors. It reveals that positive and negative shocks from the per capita cost of war, child mortality rate, and population growth rate asymmetrically affect the school enrollment rate in both the short and long runs. Furthermore, it shows that positive shocks from per capita GDP and per capita government expenditures on education increase the school enrollment rate, while their negative shocks have adverse effects, in both the short and long runs. This implies that school enrollment is highly sensitive to changes in the per capita cost of war and reacts swiftly. Moreover, the results reveal significant causality from both the positive and negative components of the per capita cost of war, per capita GDP, per capita government expenditures on education, and population growth to both the positive and negative components of the school enrollment rate. However, there is only a causal nexus from the negative component of the child mortality rate to the school enrollment rate. Based on these findings, relevant policy implications are discussed.

Xenophobia: a hindrance factor to South Africa’s ambition of becoming a developmental state

The prevalence of xenophobic violence toward foreigners has hindered South Africa’s ambition to become a developmental state since 2007, when the concept of a “democratic developmental state” was first endorsed during the African National Congress (ANC) conference in Polokwane. This ambition has also been thwarted by the inability of the post-apartheid regime to provide adequate and sustainable services to the citizens. Xenophobia has disrupted economic growth and has contributed to poor service delivery in local municipalities, thus leading to social protests. The developmental state depends mainly on a solid balance of economic growth and human development. It also leans on the capacity of the state to establish policies that address poverty and promote the expansion of solid economic opportunities. In this endeavor, migrants increase economic growth and make it sustainable, increase productivity, and promote the labor market. They also promote the labor force and human capital, economic growth, and public finance, thus enabling the realization of a developmental state. However, xenophobia has limited migrants’ contributions to economic growth and social well-being in South Africa. It has destructive effects on South Africa’s economic structure and growth, thus affecting the delivery of adequate services that would enhance its ability to achieve a developmental state. The paper recommends that there is a need for South Africa to understand that xenophobia affects economic growth and the service delivery framework. To address the prevalence of xenophobia and achieve its ambition of a developmental state, South Africa needs to hasten its responses to curb xenophobia and integrate migrants into economic opportunities. The paper adopted a qualitative research methodology and conceptual and document analysis techniques to collect data that enabled the achievement of the above assertions.

Generation of 'semi-guided' cortical organoids with complex neural oscillations.

Temporal development of neural electrophysiology follows genetic programming, similar to cellular maturation and organization during development. The emergent properties of this electrophysiological development, namely neural oscillations, can be used to characterize brain development. Recently, we utilized the innate programming encoded in the human genome to generate functionally mature cortical organoids. In brief, stem cells are suspended in culture via continuous shaking and naturally aggregate into embryoid bodies before being exposed to media formulations for neural induction, differentiation and maturation. The specific culture format, media composition and duration of exposure to these media distinguish organoid protocols and determine whether a protocol is guided or unguided toward specific neural fate. The 'semi-guided' protocol presented here has shorter induction and differentiation steps with less-specific patterning molecules than most guided protocols but maintains the use of neurotrophic factors such as brain-derived growth factor and neurotrophin-3, unlike unguided approaches. This approach yields the cell type diversity of unguided approaches while maintaining reproducibility for disease modeling. Importantly, we characterized the electrophysiology of these organoids and found that they recapitulate the maturation of neural oscillations observed in the developing human brain, a feature not shown with other approaches. This protocol represents the potential first steps toward bridging molecular and cellular biology to human cognition, and it has already been used to discover underlying features of human brain development, evolution and neurological conditions. Experienced cell culture technicians can expect the protocol to take 1 month, with extended maturation, electrophysiology recording, and adeno-associated virus transduction procedure options.

The Effectiveness of Fiscal Transfer of South Sumatra Province: Initiation of Ecological Fiscal Transfer Concept

This study identifies the effectiveness of South Sumatra Provincial Government’s financial assistance budget transfer on Poverty Levels and the Human Development Index. This fiscal transfer from the Provincial Government is to assist and support the Regency/City Governments’ budget for their development program. The problem of this study is to identify the effect of this fiscal transfer to support the Regency/City Government in reducing poverty level and increasing Human Development Index. A coefficient of determination analysis is applied to assess the effect of the provincial financial assistance to reduce poverty rates and increase the Human Development Index. Analysis is also conducted to identify opportunities for the implementation of Ecological Fiscal Transfer model for the allocation of financial assistance budget. The study analyzes data from the Regional Budget of South Sumatra Province for the last 10 years. Coefficient of determination analysis shows that the fiscal transfer in the form of financial assistance fails to explain the variation of poverty rates and the Human Development Index in the area. Following that, the study also adopted an Ecological Fiscal Transfer model to simulate the allocation of Provincial Financial Assistance. Keywords: financial assistance, ecological fiscal transfer, poverty, Human Development Index

Effects of social environments on male primate HPG and HPA axis developmental programming.

Developmental plasticity is particularly important for humans and other primates because of our extended period of growth and maturation, during which our phenotypes adaptively respond to environmental cues. The hypothalamus-pituitary-gonadal (HPG) and hypothalamus-pituitary-adrenal (HPA) axes are likely to be principal targets of developmental "programming" given their roles in coordinating fitness-relevant aspects of the phenotype, including sexual development, adult reproductive and social strategies, and internal responses to the external environment. In social animals, including humans, the social environment is believed to be an important source of cues to which these axes may adaptively respond. The effects of early social environments on the HPA axis have been widely studied in humans, and to some extent, in other primates, but there are still major gaps in knowledge specifically relating to males. There has also been relatively little research examining the role that social environments play in developmental programming of the HPG axis or the HPA/HPG interface, and what does exist disproportionately focuses on females. These topics are likely understudied in males in part due to the difficulty of identifying developmental milestones in males relative to females and the general quiescence of the HPG axis prior to maturation. However, there are clear indicators that early life social environments matter for both sexes. In this review, we examine what is known about the impact of social environments on HPG and HPA axis programming during male development in humans and nonhuman primates, including the role that epigenetic mechanisms may play in this programming. We conclude by highlighting important next steps in this research area.

Impact of the circular economy on human development: evidence from Germany

Impact of the circular economy on human development: evidence from Germany

SMEs Awareness and Preparation for Digital Transformation: Exploring Business Opportunities for Entrepreneurs in Saudi Arabia’s Ha’il Region

This study investigates how Saudi SMEs’ awareness and preparation for digital transformation impact their business performance (BP). First and foremost, in this study, we examine the impact of awareness and preparation on business performance using the intention to use (ITU) as an initial mediator. In addition, the researchers also examined the impact of awareness and preparation on business performance through intention to use and Government Support (GS), and later, intention to use and skills as serial mediators. Using a structured questionnaire based on a seven-point Likert scale, data were collected from 68 SMEs in the Ha’il region of Saudi Arabia, one of the Kingdom’s leading economic provinces. The data were analyzed through simple and serial mediation techniques through AMOS-24. The study found that SMEs’ awareness and preparation for digital transformation significantly and positively influenced their intentions to use the technology. The researchers found that intention to use, skills, and government support are significant variables that improve business performance. The research also revealed full-serial mediation between awareness and business performance and preparation and business performance, showing that intention to use and skills and intention to use and government support significantly mediate improving SMEs’ business performance. The study implications provide for SMEs’ successful digital transformation, considering the role of skills and government support, which will help SMEs improve their performance and embrace sustainability in human and economic development in Saudi Arabia. Together with policymakers, SMEs, and researchers, it will also look at the entrepreneurial potential for Saudi nationals in the run-up to Vision 2030.

Examining the Contemporary Worker and the Workplace From a Leadership-as-Practice Perspective: A HRD Opportunity

In this article the author uses the lens of leadership-as-practice (L-A-P) to analyze the concerns of the worker in the contemporary workplace and proposes both new insights and potential remediations through a post-humanistic leadership centered on practice. L-A-P is designed to probe underneath the accepted or “natural” human resource practices to uncover the power dynamics in the workplace that have led to challenges to the worker in the form of burnout, lack of autonomy, and detachment. After introducing the practice approach to the workplace, the paper interrogates the potential value of leadership being viewed as a collaborative agency constituting changes in the trajectory of prefigured work practices that can have affirmative consequences via its ethical and critical approach to human resource development.

PECARN prediction rules for CT imaging of children presenting to the emergency department with blunt abdominal or minor head trauma: a multicentre prospective validation study

The intra-abdominal injury and traumatic brain injury prediction rules derived by the Pediatric Emergency Care Applied Research Network (PECARN) were designed to reduce inappropriate use of CT in children with abdominal and head trauma, respectively. We aimed to validate these prediction rules for children presenting to emergency departments with blunt abdominal or minor head trauma. For this prospective validation study, we enrolled children and adolescents younger than 18 years presenting to six emergency departments in Sacramento (CA), Dallas (TX), Houston (TX), San Diego (CA), Los Angeles (CA), and Oakland (CA), USA between Dec 27, 2016, and Sept 1, 2021. We excluded patients who were pregnant or had pre-existing neurological disorders preventing examination, penetrating trauma, injuries more than 24 h before arrival, CT or MRI before transfer, or high suspicion of non-accidental trauma. Children presenting with blunt abdominal trauma were enrolled into an abdominal trauma cohort, and children with minor head trauma were enrolled into one of two age-segregated minor head trauma cohorts (younger than 2 years vs aged 2 years and older). Enrolled children were clinically examined in the emergency department, and CT scans were obtained at the attending clinician's discretion. All enrolled children were evaluated against the variables of the pertinent PECARN prediction rule before CT results were seen. The primary outcome of interest in the abdominal trauma cohort was intra-abdominal injury undergoing acute intervention (therapeutic laparotomy, angiographic embolisation, blood transfusion, intravenous fluid for ≥2 days for pancreatic or gastrointestinal injuries, or death from intra-abdominal injury). In the age-segregated minor head trauma cohorts, the primary outcome of interest was clinically important traumatic brain injury (neurosurgery, intubation for >24 h for traumatic brain injury, or hospital admission ≥2 nights for ongoing symptoms and CT-confirmed traumatic brain injury; or death from traumatic brain injury). 7542 children with blunt abdominal trauma and 19 999 children with minor head trauma were enrolled. The intra-abdominal injury rule had a sensitivity of 100·0% (95% CI 98·0-100·0; correct test for 145 of 145 patients with intra-abdominal injury undergoing acute intervention) and a negative predictive value (NPV) of 100·0% (95% CI 99·9-100·0; correct test for 3488 of 3488 patients without intra-abdominal injuries undergoing acute intervention). The traumatic brain injury rule for children younger than 2 years had a sensitivity of 100·0% (93·1-100·0; 42 of 42) for clinically important traumatic brain injuries and an NPV of 100·0%; 99·9-100·0; 2940 of 2940), whereas the traumatic brain injury rule for children aged 2 years and older had a sensitivity of 98·8% (95·8-99·9; 168 of 170) and an NPV of 100·0% (99·9-100·0; 6015 of 6017). The two children who were misclassified by the traumatic brain injury rule were admitted to hospital for observation but did not need neurosurgery. The PECARN intra-abdominal injury and traumatic brain injury rules were validated with a high degree of accuracy. Their implementation in paediatric emergency departments can therefore be considered a safe strategy to minimise inappropriate CT use in children needing high-quality care for abdominal or head trauma. The Eunice Kennedy Shriver National Institute of Child Health and Human Development.

What Are Barrier Islands and How Are They Affected by Climate Change?

Barrier islands are complex ecosystems that exist off the coast of every continent except Antarctica. They protect the coastline from direct impacts of storms and sea-level rise. These islands are home to people and animals, some of which are endangered. Barrier islands naturally move and change shape, but climate change and human development can prevent this movement, disrupting natural processes. Conservation of barrier islands is important for providing habitats for plants and animals as well as for protecting the coast of the mainland.

FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.

FMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors. Counts of B cells, monocytes, and DCs were low in the patients' blood, whereas the other blood subsets, including NK cells, were affected only moderately, if at all. The patients had normal counts of Langerhans cells (LCs) and dermal macrophages in the skin but lacked dermal DCs. Thus, FLT3L is required for B cell and DC development in mice and humans. However, unlike its murine counterpart, human FLT3L is required for the development of monocytes but not NK cells.

Sex-biased gene expression during neural differentiation of human embryonic stem cells

Sex-biased gene expression during neural differentiation of human embryonic stem cells